Article 3218

Title of the article

A STUDY OF THE HEPATOPROTECTIVE ACTIVITY OF WATER EKTRACTS OF HERBS CYMBOPOGON PROXIMUS, ACACIA
NILOTICA, TRIGONELLA FOENUMGRAECUM ON THE MODEL OF TOXIC HEPATITIS CAUSED BY FOUR-CHLORINE
CARBON IN WHITE RATS OF WISTAR LINE 

Authors

Inchina Vera Ivanovna, Doctor of medical sciences, professor, head of sub-department of pharmacology and clinical pharmacology with a course of pharmaceutical technology, Ogarev Mordovia State University (68 Bolshevistskaya street, Saransk, Russia), v.inchina@ya.ru
Mutvakel Abas Abdalkhamid Khusseyn, Postgraduate student, Ogarev Mordovia State University (68 Bolshevistskaya street, Saransk, Russia), dr.nutwakil2020@hotmail.com

Index UDK

616.36:615.4

DOI

10.21685/2072-3032-2018-2-3

Abstract

Background. The work is aimed at studying hepatoprotective effects of water extracts of herbs Cymbopogon proximus, Acacia nilotica, and Trigonella foenumgraecum on the model of acute toxic hepatitis induced by carbon tetrachloride.
Materials and methods. In an experiment on 40 white Wistar rats, the effect of water extracts of herbs was studied. Water extracts of the studied herbs at a concentration of 1:10 were administered intraperitoneally within 4 days after modeling
acute hepatitis. After 4 days from the beginning of the experiment, biochemical blood tests and liver histological studies were performed.
Results. Phytopreparations correct the growth of serum triglycerides and do not eliminate the development of hyperfermentemia, increased creatinine and a decrease in serum urea. The results of histological examination of the liver are more informative
for evaluating the effects of extracts of the studied herbs. It is shown that the use of aqueous extracts prevents the development of pronounced destructive changes in hepatocytes and liver parenchyma in the form of necrosis, fatty degeneration,
and inflammatory changes.
Conclusions. The obtained results testify to the effectiveness of the use of aqueous extracts of Cymbopogon proximus, Acacia nilotica, and Trigonella foenumgraecum in acute toxic liver damage. The proposed fields of application of the material obtained are experimental gastroenterology, toxicology, phytotherapy.

Key words

acute toxic hepatitis, aqueous extracts of Cymbopogon proximus, Acacia nilotica, Trigonella foenumgraecum, morphological changes in the liver

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References

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Дата создания: 24.10.2018 15:48
Дата обновления: 03.12.2018 15:55